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CK-1827452 (10 μM) reduces the maximal ATPase (kcat) 4
76(4):821-7
2020 Jul-Aug
CTNNB1 and GSK3B as compare to osteogenic medium alone on day 7
Cells treated with FPH1 also maintained their liver-specific functions
TBK1 PROTAC® 3i - CAS# 2052306-13-3 ctinib CK-1827452 (10 μM) reduces theTBK1 PROTAC 3i, CAS No. 2052306 13 3, is a Potent TANK binding kinase 1 (TBK1) Degrader. It exhibits >50 fold selectivity for TBK1 over the closely related IKK. It comprises a ligand for von Hippel Lindau (VHL) protein joined by a linker to a TBK1 targeting moiety. It brings about near complete degradation of TBK1 in mutant K Ras and wild type cancer cell lines with no significant effect of proliferation. Product information CAS Number: 2052306 13 3
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