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IC50=354 nM
Richards J
Thailanstatin A
CAS Number: 28342-31-6
InChi: InChI=1S/C64H91N19O22/c1-31(2)52(68)62(103)81-44(30-88)57(98)74-37(21-48(66)90)55(96)78-41(27-85)56(97)73-36(20-47(65)89)54(95)76-39(19-33-22-69-35-13-7-6-12-34(33)35)64(105)83-17-9-15-46(83)61(102)79-42(28-86)58(99)75-38(18-32-10-4-3-5-11-32)63(104)82-16-8-14-45(82)60(101)80-43(29-87)59(100)77-40(26-84)53(94)72-25-51(93)71-24-50(92)70-23-49(67)91/h3-7
Wf-516 6390 IC50=354 nMWf 516 is an inhibitor of 5 HT reuptake, and an antagonist of 5 HT1A and 5 HT2A receptors, with Ki of 5 nM and 40 nM for 5 HT1A receptor and 5 HT2A receptor in humans, respectively, and has potent antidepressant activity. Product information CAS Number: 310392 94 0 Molecular Weight: 502. 39 Formula: C25H25Cl2N3O4 Chemical Name: (2S) 1 [4 (3,4 dichlorophenyl)piperidin 1 yl] 3 {[2 (5 methyl 1,3,4 oxadiazol 2 yl) 1 benzofuran 4 yl]oxy}propan 2 ol Smiles:
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