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62(1):65–74
ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model
Nat Nanotechnol
22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9
J Clin Oncol
GNE-7915 - CAS# 1351761-44-8 0254 62(1):65–74GNE 7915, CAS No. 1351761 44 8, is a potent LRRK2 kinase inhibitor, which possess an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. GNE 7915 was reported as a potent (IC50=9 nM) selective (1 187 kinases), brain penetrant and non toxic inhibitor of LRRK2. Product information CAS Number: 1351761 44 8 Molecular Weight: 443. 40 Formula: C19H21F4N5O3 Synonym: GNE 7915